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A technique is described for the simultaneous and controlled random mutation of all three heavy or light chain complementaritj-determining regions (CDRs) in a single-chain Fv specific for the 0 polysaccharide of SalmoneUla serogroup B. Sense oligonucleotides were synthesized such that the central bases encoding a CDR were randomized by equimolar spiking with A, G, C, and T at a level of 10%/1 w...
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ژورنال
عنوان ژورنال: Glasnik Advokatske komore Vojvodine
سال: 1992
ISSN: 0017-0933,2683-5967
DOI: 10.5937/gakv9209017l